Question: Is Valtrex Nephrotoxic?

Is acyclovir hard on the kidneys?

Abstract.

Acute kidney injury is an unfortunate complication of acyclovir therapy secondary to crystal-induced nephropathy.

It is characterized by a decrease in renal function that develops within 24–48 hours of acyclovir administration indicated by a rapid rise in the serum creatinine..

What viruses does Valtrex treat?

Valtrex (valacyclovir) is an antiviral drug. It slows the growth and spread of the herpes virus to help the body fight the infection. Valtrex is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles (herpes zoster) in adults.

Can taking Valtrex cause an outbreak?

Even if you’re taking Valtrex, it’s still possible to have an outbreak. If you’re taking Valtrex for recurrent genital herpes and have an outbreak, it’s important to avoid sexual contact with your partner to keep the virus from spreading to them.

What are the long term side effects of Valtrex?

Another potential long-term side effect of valacyclovir usage is HUS/TTP, or hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura. These similar disorders can lead to the destruction of red blood cells and a low platelet count, preventing your blood’s ability to clot.

What medications should be avoided with kidney disease?

Kidney Disease: Medicines to AvoidPain medicines, including: … Herbal supplements, which can contain minerals like potassium that are harmful for people who have kidney disease. … Statin medicines, such as atorvastatin, lovastatin, and simvastatin, for high cholesterol.Diabetes medicines, including insulin and metformin.More items…

How long can I stay on Valtrex?

Valacyclovir is usually prescribed for seven days for shingles, with a typical dosage of 1,000 mg three times per day. Just like with HSV-1 and HSV-2, it’s important to start treatment as soon as you notice shingles symptoms.

What drugs are considered nephrotoxic?

The nephrotoxic effects of cyclosporine, aminoglycoside antibiotics, cisplatin, amphotericin B, beta-lactam antibiotics and indomethacin are reviewed. These drugs were chosen because they are among the most frequent causes of renal injury in children.

Do antivirals weaken immune system?

Whereas AZT, ribavirin, or ganciclovir were antiproliferative, ddI or acyclovir had little, if any, effect on PBMC mitogenesis. The inhibitory effects of antivirals on immune cells may contribute to the immune deterioration observed in patients following prolonged use of the drugs.

Can Valtrex weaken your immune system?

However, because they suppress the immune system, these medicines also suppress the ability of the body to fight infection. Valaciclovir is therefore given to people who have received an organ transplant, in order to help the body kill off any CMV virus.

What is the first sign of kidney problems?

Signs and symptoms of acute kidney failure may include: Decreased urine output, although occasionally urine output remains normal. Fluid retention, causing swelling in your legs, ankles or feet. Shortness of breath.

Who should not take valacyclovir?

The following people should not take valacyclovir for the treatment of herpes infections: Patients with sensitivity or an allergy to any of the following medications should not use Valacyclovir: Acyclovir, Famciclovir, ganciclovir, penciclovir, valacyclovir, or valganciclovir.

Does antiviral kill virus?

Antivirals work to prevent viral infection and spread Antivirals treat infections by preventing the virus from spreading throughout your body. In other words, they don’t kill the virus, outright, which makes developing antivirals tricky.

What foods help repair kidneys?

A DaVita Dietitian’s Top 15 Healthy Foods for People with Kidney DiseaseRed bell peppers. 1/2 cup serving red bell pepper = 1 mg sodium, 88 mg potassium, 10 mg phosphorus. … Cabbage. 1/2 cup serving green cabbage = 6 mg sodium, 60 mg potassium, 9 mg phosphorus. … Cauliflower. … Garlic. … Onions. … Apples. … Cranberries. … Blueberries.More items…

Can Valtrex cause kidney problems?

Valtrex is less likely to cause kidney problems than Acyclovir. Acyclovir is much less expensive because it has been available as a generic drug for a long time.

Is valacyclovir an immunosuppressant?

The reviewer stated that Valtrex is an antiviral drug. It is taken orally. As such, it is a systemic treatment. However, it is not an immunosuppressive drug such as a corticosteroid.

What color is urine when your kidneys are failing?

When kidneys are failing, the increased concentration and accumulation of substances in urine lead to a darker color which may be brown, red or purple. The color change is due to abnormal protein or sugar, high levels of red and white blood cells, and high numbers of tube-shaped particles called cellular casts.

What are side effects of Valtrex?

Side effects of Valtrex include:headache,dizziness,tired feeling,depression,nausea,vomiting,stomach pain,joint pain,More items…•

Why does acyclovir cause renal failure?

Acyclovir-induced nephrotoxicity is typically evident by an increase in the plasma creatinine level, abnormal urine sediment, or acute renal injury [8]. Acyclovir is rapidly excreted in the urine via glomerular filtration and tubular secretion, and reaches high concentrations in the tubular lumen.

Can Valtrex treat other viruses?

Valacyclovir is used to treat infections caused by herpes and varicella-zoster viruses, such as genital herpes, cold sores, shingles, and chicken pox. Approved to treat cold sores in children aged older than 12 and for the treatment of chickenpox in children aged two to 18 years.

Can Valtrex stop an outbreak?

For the treatment of genital herpes outbreaks, Valtrex, acyclovir (Zovirax), and famciclovir (Famvir) appear to be equally effective. Zovirax is only approved to treat initial and recurrent outbreaks. Compared to Famvir, Valtrex appears to be more effective at suppressing viral shedding when taken daily.

How much does valtrex reduce risk of transmission 2020?

One study of valacyclovir showed that taking suppressive therapy can reduce the chances of transmitting the virus by approximately one-half.